Well, yesterday, he announced that he'd wrapped filming, and was done by Tweeting:

Chris was cast back in March of 2010.

He first played Steve Rogers AKA. Captain America in 'Captain America: The First Avenger'.  He continued in 'The Avengers', 'Captain America: The Winter Soldier', 'Avengers: Age of Ultron', 'Captain America: Civil War', and 'Avengers: Infinity War', plus cameos in several other Marvel films. Since he confirmed he;s now done, can we assume ol' Steve will DIE for good in the next Avengers? I wouldn't be surprised.

As for what's next? Well Deadline says Chris is joining Daniel Craig in the upcoming murder mystery 'Knives Out'.